Table 1.
Top 14 candidate biomarkers with positive and negative fold changes in untreated DMD patients compared to controls, as measured by SomaScan across two independent cohorts.
| Uniprot accession number | Protein name | VBP15-004 cohort (in this study) |
FOR-DMD cohort (in this study) |
||
|---|---|---|---|---|---|
| Fold change | adj. P. val. | Fold change | adj. P. val. | ||
| Increased in DMD | |||||
| Q5VTT5 | Myomesin-3 | + 29.0 | 6.57E-53 | + 37.66 | 9.7E-48 |
| P54296 | Myomesin-2 | + 80.2 | 9.86E-52 | + 70.05 | 1.7E-33 |
| P48788 | Troponin I, fast skeletal muscle | + 50.5 | 6.8E-51 | + 48 | 1.55E-45 |
| P06732 | Creatine kinase M | + 53.9 | 1.33E-45 | + 47.96 | 1.3E-46 |
| P35609 | Alpha-actinin-2 | + 151.4 | 1.1E-44 | + 202.6 | 1.5E-45 |
| Q00872 | Myosin-binding protein C, slow-type | + 86.6 | 5.1E-44 | + 128 | 2.7E-46 |
| P08590 | Myosin light chain 3 | + 44.3 | 5.3E-43 | + 66.1 | 7.4E-46 |
| Decreased in DMD | |||||
| P01024 | Complement C3b | - 43.6 | 1.23E-27 | - 8.0 | 1.05E-10 |
| Q9Y5Y2 | Cytosolic Fe-S cluster assembly factor NUBP2 | - 2.6 | 6.24E-23 | - 1.2 | 1.51E-02 |
| P01024 | Complement C3b, inactivated | - 4.3 | 5.30E-20 | - 2.0 | 3.74E-08 |
| Q13508 | Ecto-ADP-ribosyltransferase 3 | - 2.2 | 2.75E-18 | - 2.5 | 4.97E-21 |
| Q99727 | Metalloproteinase inhibitor 4 | - 1.7 | 5.49E-18 | - 1.5 | 1.36E-11 |
| Q96EE4 | Coiled-coil domain-containing protein 126 | - 1.6 | 6.97E-18 | - 1.6 | 4.13E-14 |
| Q9UHA7 | Interleukin-36 alpha | - 3.8 | 2.60E-15 | - 2.1 | 5.62E-08 |