Table 2.
Pharmacokinetic parameters for cancellous bone 5 mm and 10 mm
| Pharmacokinetic parameters | 2 mL CarboCell | 4 mL CarboCell | Difference | P-value | ||
|---|---|---|---|---|---|---|
| AUC0 − 24 h, min•µg/mL (95%CI) | ||||||
| Cancellous bone (5 mm) | N = 8 | 202.7 (164.0; 641.3) | N = 2 | 884.9 (407.7; 1362.2) | 482.2 (-51.3; 1015.83) | 0.071 |
| Cancellous bone (10 mm) | N = 8 | 475.0 (164.2; 785.7) | N = 2 | 296.9 (-324.6; 918.5) | -178.0 (-872.9; 516.9) | 0.595 |
| Cmax, µg/mL (95% CI) | ||||||
| Cancellous bone (5 mm) | N = 8 | 0.7 (0.01; 1.4) | N = 2 | 2.2 (0.8; 3.6) | 1.5 (0.0001;3.0) | 0.05 |
| Cancellous bone (10 mm) | N = 8 | 0.8 (0.2; 1.3) | N = 2 | 0.3 (-0.8; 1.3) | -0.5 (-1.7; 0.7) | 0.384 |
Area under the curve from time 0 to 24 h (AUC0 − 24 h); Peak drug concentration (Cmax)
AUC0 − 24 h and Cmax are given as medians