Table 3.

Association between genetic predictions of causal risk for metabolic syndrome and idiopathic pulmonary fibrosis.

Exposure	Outcome	nSNPs	Methods	OR (95% CI)	P
Metabolic syndrome	Idiopathic pulmonary fibrosis	188	IVW	1.0009 (0.9998–1.002)	.125
			MR-Egger	1.0011 (0.9981–1.0042)	.471
			Weighted median	1.0003 (0.9986–1.0021)	.714
			Weighted mode	1.0007 (0.9982–1.0032)	.595
Waist circumference		322	IVW	1.0016 (1.0006–1.0025)	.001
			MR-Egger	1.0016 (0.9988–1.0044)	.254
			Weighted median	1.0012 (0.9996–1.0027)	.134
			Weighted mode	1.0005 (0.9978–1.0031)	.742
Essential (primary) hypertension		69	IVW	1.0028 (0.9965–1.0092)	.388
			MR-Egger	0.9937 (0.9703–1.0176)	.603
			Weighted median	1 (0.9909–1.0091)	.998
			Weighted mode	0.9953 (0.9776–1.0134)	.613
Fasting blood glucose		64	IVW	1.0001 (0.9985–1.0016)	.921
			MR-Egger	1 (0.9971–1.0028)	.984
			Weighted median	1.0006 (0.9984–1.0028)	.572
			Weighted mode	1.0004 (0.9984–1.0024)	.712
HDL cholesterol		86	IVW	1.0006 (1.0001–1.0012)	.033
			MR-Egger	1.0014 (1.0004–1.0023)	.006
			Weighted median	1.0009 (0.9999–1.0018)	.064
			Weighted mode	1.0008 (1–1.0016)	.047
Triglycerides		54	IVW	0.9994 (0.9986–1.0002)	.129
			MR-Egger	0.9995 (0.9982–1.0009)	.492
			Weighted median	0.999 (0.9979–1.0002)	.095
			Weighted mode	0.999 (0.9979–1.0001)	.073

CI = confidence interval, IVW = inverse-variance weighted, MR = Mendelian randomization, OR= odds ratio, SNP = single nucleotide polymorphism.