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. 2025 Nov 18;8:0883. doi: 10.34133/research.0883

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Copyright © 2025 Jieliu Li et al.

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Fig. 7. — (A) Schematic diagram of intravenous TPP@(CeO₂+ROF) targeting mitochondria to release drugs, exerting protective effects against ischemic stroke. (B) Electron microscopy images of TPP@(CeO₂+ROF) aggregation in mitochondria. (C) Mitosox Red fluorescent probe was used to assess mitochondrial ROS levels following treatment with each experimental group. (D) TPP@(CeO₂+ROF) treatment modulated CD86 and CD206 expression in microglia [180]. Copyright 2024, American Chemical Society. (E) Schematic diagram demonstrating how RMVs modulate oxidative stress in activated macrophages to aid wound healing. (F) RMV normalizes mtROS levels in LPS-affected macrophages. (G) 3-HPA reverses the impact of LPS on mitochondrial permeability in macrophages. (H) RMV reverses the classical macrophage activation pathway promoted by LPS [182]. Copyright 2024, Wiley-VCH GmbH.