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Serum proinflammatory cytokine profile in healthy Buffalo rats after hepatic arterial infusion of VSV. The animals were injected with 1.3 × 107 PFU rVSV-GFP (n = 8), maximum tolerated dose, or 7.2 × 108 PFU rVSV-GFP (n = 11), and blood samples were collected from the retro-orbital vein 1 day later. Serum levels of a panel of proinflammatory rat cytokines (IL-6, TNF-α, IL-1β, and IFN-γ) were determined using commercially available enzyme-linked immunosorbent assays.
