TABLE 3.
Effect of decreased population size and increased mutation rate on the evolution of drug resistancea
| Ne (effective population size) | μ (mutation rate) | Time (fixation) |
|---|---|---|
| 10,000 | 3 × 10−5 | 212 |
| 1,000 | 3 × 10−4 | 174 |
| 100,000 | 3 × 10−5 | 179 |
| 10,000 | 3 × 10−4 | 143 |
a
Increased mutation rates caused by drug treatment result in a faster evolution of drug resistance even if the effective population size is reduced by the same factor or more. Two different scenarios are shown. The following parameters are used: wab = 1, wAb = waB = 1.1, wAB = 1.21, f = 0.75, and r = 0.5.