FIG. 8.

IFN-induced inhibition of FLUAV and SFV multiplication in HuH6 and Huh-7 cells. FLUAV (A) and SFV (B) plaque formation in HuH6 cells is shown. Semiconfluent monolayer cultures were incubated with 1,000-IU/ml IFN-α or IFN-γ or were left untreated. After 24 h, cells were infected with serial 10-fold dilutions of stock virus, plaques were allowed to develop for 72 h under soft agar, and remaining cells were fixed and stained with crystal violet. For FLUAV (C) and SFV (D) plaque formation in Huh-7 cells, the experiment was performed as described above.