TABLE 2.
Quantification of IFN-induced gene expression in naive HuH6 and Huh-7 cells
| Genea | Signalb,d
|
Fold changec,d
|
Signalb,e
|
Fold changec,e
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mock | IFN-α | IFN-γ | IFN-α | IFN-γ | Mock | IFN-α | IFN-γ | IFN-α | IFN-γ | |
| cig5 | 0.0 | 96 | 3.7 | 2,462 | 95 | 0.1 | 209 | 5.8 | 2,887 | 81 |
| G1P2 | 137 | 6,934 | 762 | 51 | 5.6 | 66 | 5021 | 914 | 77 | 14 |
| G1P3 | 2.9 | 657 | 41 | 224 | 14 | 0.9 | 945 | 75 | 1,043 | 84 |
| GBP1 | 0.8 | 5.2 | 1,152 | 6.2 | 1,362 | 9.3 | 184 | 4,046 | 20 | 435 |
| GBP2 | 12 | 13 | 1,082 | 1.1 | 89 | 390 | 665 | 2,672 | 1.7 | 6.9 |
| IFI-27 | 76 | 7,991 | 1,522 | 106 | 20 | 7.6 | 787 | 101 | 104 | 13 |
| IFI-T4 | 24 | 825 | 449 | 34 | 19 | 16 | 797 | 646 | 48 | 39 |
| IFI-T5 | 1.5 | 265 | 80 | 175 | 53 | 41 | 506 | 197 | 12 | 4.8 |
| IP10 | 0.3 | 3.6 | 256 | 11 | 755 | 67 | 1,089 | 8,702 | 16 | 131 |
| MxA | 4.2 | 340 | 20 | 80 | 4.6 | 46 | 24,896 | 2,763 | 540 | 60 |
| OAS1 | 0.76 | 983 | 21 | 1,288 | 27 | 7.0 | 1,391 | 102 | 198 | 15 |
| OAS2 | 2.4 | 2,384 | 180 | 987 | 75 | 1.9 | 1,154 | 97 | 599 | 50 |
| PKR | 3.3 | 9.6 | 4.6 | 2.9 | 1.4 | 5.1 | 12 | 10 | 2.4 | 2.0 |
| STAT1 | 176 | 1,667 | 2,749 | 10 | 16 | 180 | 2,151 | 1,695 | 12 | 9 |
| simSTAT1 | 16 | 209 | 293 | 13 | 18 | 19 | 253 | 242 | 14 | 13 |
Database accession numbers are given in the Materials and Methods.
mRNA copy number/100,000 β-actin mRNA copies 24 h after the IFN treatment.
Signal in IFN-treated cells per signal in mock-treated cells.
Values are for naive HuH6 cells.
Values are for naive Huh-7 cells.