TABLE 3.

Quantification of IFN-induced gene expression in HuH6 cells with and without HCV replicons

Genea and cell line	Signalb			Fold changec
	Mock	IFN-α	IFN-γ	IFN-α	IFN-γ
HuH6 Con1 replicon cells
GBP1	2.4	18	933	7.6	395
IP10	0.7	19	106	26	147
MxA	14	183	38	13	2.7
OAS1	1.3	1,641	15	1,291	12
STAT1	321	2,267	3,312	7.1	10
HuH6 JFH-1 replicon cells
GBP1	1.8	40	223	23	126
IP10	0.5	330	39	648	77
MxA	18	3973	71	224	4.0
OAS1	3.8	4553	37	1,211	9.7
STAT1	222	4,278	1,366	19	6.2
Naive HuH6 cells
GBP1	0.8	3.7	586	4.9	768
IP10	0.1	5.5	176	105	3,325
MxA	2.9	563	18	196	6.3
OAS1	1.0	1,943	22	2,041	23
STAT1	349	3,467	3,565	9.9	10

^aDatabase accession numbers are given in Materials and Methods.

^bmRNA copy number per 100,000 β-actin mRNA copies 24 h after IFN treatment.

^cSignal in IFN-treated cells per signal in mock-treated cells.