FIG. 4.
Post- and preimmunization challenge with VACV WR. (A and B) In two separate experiments, groups of five 7-week-old female BALB/c mice were immunized with 100 μg of anti-A33 or -L1 MAbs or a combination of both 1 day prior to challenge (-1) or 2 days after challenge (+2) i.n. with 106 PFU of VACV WR. The mice were weighed daily, and the number (N/10) that died or was sacrificed is indicated. (C and D) Groups of five mice were challenged as described above with 5 × 105 PFU of VACV WR. The number (N/5) that died or were sacrificed is indicated. Percentages of initial mean weights ± standard errors of the means are shown.