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Hepatic HMG-CoA reductase, ACAT and cholesterol 7α-hydroxylase activities (CYP7) guinea pigs fed a control diet, low dose MTPi (LDI), high dose MTPi (HDI) or atorvastatin1
| Diets | HMG-CoA Reductase | ACAT | CYP7 |
| (pmol/min.mg) | |||
| Control | 1.8 ± 0.8 | 0.8 ± 0.4 | 1.7 ± 1.8 |
| LDI | 2.7 ± 0.8 | 2.2 ± 0.9 | 1.2 ± 0.5 |
| HDI | 2.5 ± 1.4 | 3.5 ± 2.4 | 0.6 ± 0.7 |
| Atorvastatin | 3.4 ± 2.9 | 4.4 ± 3.1 | 0.7 ± 0.4 |
1Data are presented as mean ± SD for n = 3–7 guinea pigs per group.
