Table 1.

Errors between the dynamic model and the hybrid model of the pathway shown in Fig. 2a. The maximum errors were measured within one numerical integration step. "Perturbation" denotes whether the errors were measured under a steady-state condition (-) or after a two-fold increase of metabolite A (+)

	Perturbation	Maximum error (concentration)	Maximum error (reaction rate)
Boundary	-	0	0
	+	8.000 × 10-11 (C)	0
Static part	-	0	8.592 × 10-16 (E_CD)
	+	4.000 × 10-11 (D,E,F,G)	8.889 × 10-6 (E_CD)