Table 3. Previous case reports about chemotherapy for TAS.
| Author | Year | Country | Patient (n) | Treatment | Regimen (n) | Follow-up status |
|---|---|---|---|---|---|---|
| Rhomberg16) | 2004 | Austria | 9 | Surgical resection + adjuvant CHT(1) Surgical resection + adjuvant CRT(8) |
RAZ(6) | Median: 48.5 months (range, 0.5–196 months) |
| RAZ + VND(2) | Mean: 13.75 months | |||||
| DOX + VND(1) | 1 month | |||||
| Yilmazlar20) | 2005 | Turkey | 1 | Total thyroidectomy + adjuvant CHT | IFO + DOX | 12 weeks, DED |
| Fulciniti21) | 2008 | Italy | 1 | Total thyroidectomy + adjuvant CHT | Details unknown | 15 months |
| Isa22) | 2009 | Malaysia | 1 | Hemithyroidectomy + CHT | PAC | 7 months, DED |
| Binesh23) | 2011 | Iran | 1 | Neoadjuvant CHT + RT | IFO + DOX | 4 months, DED |
| Stacchiotti24) | 2012 | Italy | 1 | Neoadjuvant CHT | GEM | 14 months |
| Innaro25) | 2013 | Italy | 1 | Total thyroidectomy + adjuvant CHT | IFO + DOX+ dacarbazine + mesna | 22 months, NED |
| Collini5) | 2016 | Italy | 5 | Surgical resection + neoadjuvant CHT(1) | PAC + IFO + EPI | 36 months, DED |
| Surgical resection + adjuvant CHT(3) | IFO + DOX as adjuvant and PAC after 2nd surgery at relapse | 9 months, DED | ||||
| Surgical resection + adjuvant CRT(1) | IFO + EPI | 82 months, NED | ||||
| PAC for 1 cycle and GEM for 3cycles as neoadjuvant, and IFO + EPI as adjuvant | 70 months, NED | |||||
| IFO + EPI as adjuvant after 1st surgery and neoadjuvant before 2nd surgery at relapse | 59 months, NED | |||||
| Crawford26) | 2017 | USA | 1 | Total thyroidectomy + adjuvant CHT | PAC | 14 months, NED |
| Marina27) | 2018 | Italy | 1 | Total thyroidectomy + adjuvant CHT | IFO + EPI + mesna | 62 months, NED |
| Kondapalli28) | 2019 | USA | 1 | Total thyroidectomy + adjuvant CRT | IFO + DOX + mesna | 23 months, NED |
| Bravaccini29) | 2021 | Italy | 1 | Hemithyroidectomy + CHT | DOX | 6 months |
| Probst30) | 2021 | Germany | 1 | Total thyroidectomy + adjuvant CHT | PAC | 4 months, DED |
| Bala31) | 2022 | Portugal | 1 | Total thyroidectomy + adjuvant CRT | PAC, DOX, GEM, docetaxel, and pazopanib | 29 months, DED |
| Lu32) | 2023 | China | 1 | Subtotal thyroidectomy + adjuvant CHT | IFO + EPI | 31 months, NED |
| Gurluler33) | 2024 | Turkey | 1 | Hemithyroidectomy + CHT | PAC | Unknown, DED |
| Our case | 1 | Hemithyroidectomy + CHT | PAC | 5 months, DED | ||
CHT, chemotherapy; CRT, chemoradiotherapy; DED, died of disease; DOX, doxorubicin; EPI, epirubicin; GEM, gemcitabine; IFO, ifosfamide; NED, no evidence of disease; PAC, paclitaxel; RAZ, razoxane; RT, radiotherapy; VND, vindesine