Fig. 7. A groove at the interface between PH and BEACH domains. (A) Molecular surface of the PH–BEACH domains, with the PH domain in green and BEACH domain in purple. Strictly conserved residues are colored in yellow, and mostly conserved residues in cyan. (B) Docking of residues in the ε4–ε5 loop of one BEACH molecule into the groove of the other in the crystal. The molecular surface of the second PH–BEACH molecule (residue numbers 2137′–2553′) is colored according to electrostatic potential. Produced with Grasp (Nicholls et al., 1991).