Table 2.

Immunoreactivity of aSyn antibodies in the substantia nigra of PD and controls donors and in colon specimen of an individual with incidental enteric aSyn pathology and control individuals. LB: Lewy bodies, LN: Lewy neurites, IM fibers: intramuscular nerve fibers, IR: immunoreactivity. Staining pattern: strong ++, moderate +, weak ±, absent -.

	Substantia nigra			Colon			Unspecific IR
Antibodies	neuronal (controls)	LB (PD)	LN (PD)	ganglia (controls)	IM fibers (controls)	aSyn deposits
Syn211	+	++	+	++	++	+	mucosa, immune cells
N-term aSyn	+	++	+	++	++	+	mucosa, immune cells, cell nuclei
P-aSyn - D1R1R	-	++	++	±	-	++	very low
P-aSyn - EP1536Y	-	++	±	-	-	+	very low
P-aSyn - MJF-R13	-	++	++	++	+	+	mucosa, immune cells, cell nuclei
P-aSyn - pSyn#64	-	++	++	+	-	++	mucosa (faint)
P-Y39 aSyn	-	++	++	±	-	++	immune cells (faint)
5G4	±	++	±	±	-	++	mucosa, immune cells
MJFR−14	+	++	+	++	++	+	mucosa, immune cells