Table 5.

Diagnostic performance and agreement with the composite reference standard for mNGS and RT-PCR.

Method		Attributed by Xpert and clinical diagnosis		Sensitivity	Specificity	ORA
		TB	Non-TB	(95% CI)	(95% CI)	(95% CI)
mNGS	+	48	0	92.31	100	99.28
	–	4	504	(81.46-97.86)	(99.27-100)	(98.17-99.80)
RT-PCR	+	47	0	90.39	100	99.10
	–	5	504	(78.97-96.80)	(99.27-100)	(97.91-99.71)

TB, tuberculosis; ORA, overall agreement; +, positive; -, negative.

Note: A positive result on the Xpert assay or a clinical diagnosis of tuberculosis is considered the standard for diagnosing tuberculosis.