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Responder rates for different efficacy parameters and their combinations in chronic migraine
| Efficacy parameter | Responder rate | Significance vs. highest responder rate |
|---|---|---|
| MIDAS score reduced by ≥ 30% | 48.2% | p < 0.00001 |
| HIT-6 score reduced by ≥ 5 points | 55.0% | p < 0.00001 |
| Monthly migraine days reduced by ≥ 30% | 58.2% | p < 0.00001 |
| MIDAS or migraine days | 68.2% | p = 0.0316 |
| MIDAS or HIT-6 | 70.9% |
n.s p = 0.1264 |
| HIT-6 or migraine days | 71.8% |
n.s p = 0.1876 |
| MIDAS or HIT-6 or migraine days | 77.7% | – |
