Skip to main content
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1994 Oct;58(4):309–312.

Approche directe pour la mise en évidence des phénomènes radicalaires lors de myopathie postanesthésique équine: étude préliminaire.

Direct approach for demonstrating free radical phenomena during equine postanesthetic myopathy: preliminary study

D Serteyn 1, J Pincemail 1, E Mottart 1, I Caudron 1, C Deby 1, G Deby-Dupont 1, C Philippart 1, M Lamy 1
PMCID: PMC1263720  PMID: 7889465

Abstract

This preliminary study demonstrated the existence of a free radical generation during an experimental postischemic muscular reperfusion in a halothane anesthetized horse. The authors used alpha-phényl-N-tert-butylnitrone as a spin trap agent and the electronic paramagnetic resonance method to observe in vivo a free radical generation.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolli R., Patel B. S., Jeroudi M. O., Lai E. K., McCay P. B. Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest. 1988 Aug;82(2):476–485. doi: 10.1172/JCI113621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coghlan J. G., Flitter W. D., Holley A. E., Norell M., Mitchell A. G., Ilsley C. D., Slater T. F. Detection of free radicals and cholesterol hydroperoxides in blood taken from the coronary sinus of man during percutaneous transluminal coronary angioplasty. Free Radic Res Commun. 1991;14(5-6):409–417. doi: 10.3109/10715769109093429. [DOI] [PubMed] [Google Scholar]
  3. Farber J. L. The role of calcium in cell death. Life Sci. 1981 Sep 28;29(13):1289–1295. doi: 10.1016/0024-3205(81)90670-6. [DOI] [PubMed] [Google Scholar]
  4. Friend S. C. Postanesthetic myonecrosis in horses. Can Vet J. 1981 Dec;22(12):367–371. [PMC free article] [PubMed] [Google Scholar]
  5. Garlick P. B., Davies M. J., Hearse D. J., Slater T. F. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Circ Res. 1987 Nov;61(5):757–760. doi: 10.1161/01.res.61.5.757. [DOI] [PubMed] [Google Scholar]
  6. Grandy J. L., Steffey E. P., Hodgson D. S., Woliner M. J. Arterial hypotension and the development of postanesthetic myopathy in halothane-anesthetized horses. Am J Vet Res. 1987 Feb;48(2):192–197. [PubMed] [Google Scholar]
  7. Lindsay W. A., McDonell W., Bignell W. Equine postanesthetic forelimb lameness: intracompartmental muscle pressure changes and biochemical patterns. Am J Vet Res. 1980 Dec;41(12):1919–1924. [PubMed] [Google Scholar]
  8. Lindsay W. A., Robinson G. M., Brunson D. B., Majors L. J. Induction of equine postanesthetic myositis after halothane-induced hypotension. Am J Vet Res. 1989 Mar;50(3):404–410. [PubMed] [Google Scholar]
  9. McCord J. M. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985 Jan 17;312(3):159–163. doi: 10.1056/NEJM198501173120305. [DOI] [PubMed] [Google Scholar]
  10. Norman W. M., Court M. H., Dodman N. H., Pipers F. S. Measurement of muscle surface capillary blood flow by laser Doppler flowmetry. Vet Surg. 1992 Nov-Dec;21(6):491–493. doi: 10.1111/j.1532-950x.1992.tb00088.x. [DOI] [PubMed] [Google Scholar]
  11. Pincemail J., Defraigne J. O., Franssen C., Defechereux T., Canivet J. L., Philippart C., Meurisse M. Evidence of in vivo free radical generation by spin trapping with alpha-phenyl N-tert-butyl nitrone during ischemia/reperfusion in rabbit kidneys. Free Radic Res Commun. 1990;9(3-6):181–186. doi: 10.3109/10715769009145675. [DOI] [PubMed] [Google Scholar]
  12. Serteyn D., Lavergne L., Coppens P., Mottart E., Philippart C., Micheels M., Lamy M. Equine post anaesthetic myositis: muscular post ischaemic hyperaemia measured by laser Doppler flowmetry. Vet Rec. 1988 Jul 30;123(5):126–128. doi: 10.1136/vr.123.5.126. [DOI] [PubMed] [Google Scholar]
  13. Serteyn D., Mottart E., Deby C., Deby-Dupont G., Pincemail J., Philipart C., Lamy M. Equine postanaesthetic myositis: a possible role for free radical generation and membrane lipoperoxidation. Res Vet Sci. 1990 Jan;48(1):42–46. [PubMed] [Google Scholar]
  14. Tortolani A. J., Powell S. R., Misík V., Weglicki W. B., Pogo G. J., Kramer J. H. Detection of alkoxyl and carbon-centered free radicals in coronary sinus blood from patients undergoing elective cardioplegia. Free Radic Biol Med. 1993 Apr;14(4):421–426. doi: 10.1016/0891-5849(93)90091-8. [DOI] [PubMed] [Google Scholar]
  15. Trim C. M., Mason J. Post-anaesthetic forelimb lameness in horses. Equine Vet J. 1973 Apr;5(2):71–76. doi: 10.1111/j.2042-3306.1973.tb03197.x. [DOI] [PubMed] [Google Scholar]
  16. Van Belle H., Wynants J., Xhonneux R., Flameng W. Changes in creatine phosphate, inorganic phosphate, and the purine pattern in dog hearts with time of coronary artery occlusion and effect thereon of mioflazine, a nucleoside transport inhibitor. Cardiovasc Res. 1986 Sep;20(9):658–664. doi: 10.1093/cvr/20.9.658. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES