. 2025 Sep 3;16(11):e00916. doi: 10.14309/ctg.0000000000000916

Table 3.

Secondary outcomes

Analysis	Cases	Control	Method	AUC	Accuracy (%)	Sens (%)	Spec (%)	PPV (%)	NPV (%)
Early CRC vs control	22	101	RF	0.76	80.70	88.20	47.60	88.10	45.50
Early CRC vs control	22	101	XG Boost	0.71	77.40	88.20	27.30	84.90	33.00
Advanced CRC vs control	83	101	RF	0.70	65.60	72.50	57.10	67.00	62.70
Advanced CRC vs control	83	101	XG Boost	0.74	68.60	62.00	72.80	72.50	62.10
Early vs advanced CRC	22	83	RF	0.73	75.70	32.50	92.20	41.20	83.00
Early vs advanced CRC	22	83	XG Boost	0.64	68.70	41.70	75.80	31.00	82.9
Metastasis CRC vs control	42	101	RF	0.71	73.60	88.20	38.10	77.60	57.10
Metastasis CRC vs control	42	101	XG Boost	0.74	72.20	84.30	42.90	78.20	52.90
Right hemicolon vs control	27	101	RF	0.67	73.80	86.30	28.60	81.30	33.30
Right hemicolon vs control	27	101	XG Boost	0.65	75.40	84.30	42.90	85.00	42.90
Left hemicolon vs control	19	101	RF	0.80	85.20	96.10	30.00	87.50	55.6
Left hemicolon vs control	19	101	XG Boost	0.74	83.60	96.00	20.00	86.00	42.9.00
Rectum vs control	56	101	RF	0.71	70.90	82.40	50.00	75.00	60.90
Rectum vs control	56	101	XG Boost	0.70	65.80	72.50	53.60	74.00	51.70

AUC, area under the curve; XGBoost, extreme gradient boosting; CRC, colorectal cancer; NPV, negative predictive value; PPV, positive predictive value; RF, random forest.