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[Preprint]. 2025 Nov 5:2025.11.03.686369. [Version 1] doi: 10.1101/2025.11.03.686369

Figure 2. Chemical depolymerization of F-actin rescues cilia length in Specc1l mutants.

Figure 2.

A. Quantification of primary cilia length in mouse embryonic fibroblasts (MEFs) from WT, SpecclΔEx4/ΔEx4, and Specc1lΔCCD2/ΔCCD2 treated with DMSO (vehicle) and Jasplakinolide (n= 65/genotype, *** <0.0004, ****<0.0001). B. Quantification of primary cilia length in WT, Specc1lΔEx4/ΔEx4, and Specc1lΔCCD2/ΔCCD2 MEFs treated with DMSO and Latrunculin B (LatB) (n= 70/genotype, *** 0.0006, ****<0.0001, Error bars represent 95% CI). Data are shown from 3 different experiments.