Table 2.
Timing of variable measurements throughout study visit.
|
|
Baseline | 4 h post drug | Gas delivery | 60 min post gas | 120 min post gas |
| Adverse events | ✓ | ✓ | ✓ | ✓ | ✓ |
| Vital signs (HRa/BPb) | ✓ | ✓ | ✓ | ✓ | ✓ |
| Participant-reported symptoms | ✓ | ✓ |
|
✓ | ✓ |
| Borg dyspnea scale |
|
|
✓ |
|
|
| Laboratory tests | ✓ | ✓ | ✓ |
|
|
| Minute ventilation | ✓ | ✓ | ✓ | ✓ | ✓ |
| MIFc | ✓ | ✓ |
|
✓ |
|
| PCFd | ✓ | ✓ |
|
|
✓ |
| MIPe | ✓ | ✓ |
|
✓ |
|
| SNIPf | ✓ | ✓ |
|
|
✓ |
| Pinch force | ✓ | ✓ |
|
|
✓ |
aHR: heart rate.
bBP: blood pressure.
cMIP: maximal inspiratory pressure.
dPCF: peak cough flow.
eMIP: maximal inspiratory pressure.
fSNIP: sniff nasal inspiratory pressure.