Fig. 1.

Peroneal Functional Index (PFI) and relative weight of the tibialis anterior target muscle. A The PFI was measured every week from W1 to W12 post-surgery. A significative improvement was observed from W7 to W12 in the fEV treated group when compared with VE and GS groups. A significative improvement is also observed in the cEV treated group at W7, 8, 11 and 12 when compared with GS, and at W7, 8, 9, 11 and 12 when compared with VE group. B The relative weight of the tibialis anterior was measured at W12 post-surgery. The muscle weight/body weight ratio was the same between the four groups. 1 symbol: p < 0.05; 2 symbols: p < 0.01; 3 symbols: p < 0.001. Dotted line, mean value of Control. GS, Gold Standard; VE, Vein; VE-cEV, Vein-cryoconserved extracellular vesicles; VE-fEV, Vein-freshly purified extracellular vesicles; W, Week