Fig. 2.

Muscle mechanical properties. A The fEV treated group displays a significant decrease in MCR/A ratio compared with VE and GS groups (p < 0.01). Injection of fEVs allowed to maintain a phenotype close to Control group (dotted line). No difference was observed between VE-cEV group and VE, GS and VE-fEV groups. B Concerning the MRR/A ratio, only the VE-fEV treated group exhibits a significant reduction of the ratio when compared with the GS group (p < 0.05) but no difference was observed with the two other groups (VE and VE-cEV). 1 symbol: p < 0.05; 2 symbols: p < 0.01; 3 symbols: p < 0.001. Dotted line, mean value of Control; GS, Gold Standard; VE, Vein; VE-cEV, Vein-cryoconserved extracellular vesicles; VE-fEV, Vein-freshly purified extracellular vesicles