Fig. 3.

Nerve response to afferent stimulation. A Compared with GS group, responses associated to electrically induced fatigue were similar in VE animals, even when fEVs or cEVs were injected in the vein conduit. B No significant increase was observed in VE animals, even when either fEVs or cEVs were added in the vein chamber when compared with GS group, after injection of lactic acid. C The metabosensitive afferent responses to potassium chloride (KCl) were similar in all groups. OEMSC-derived EVs do not improve the recovery. 1 symbol: p < 0.05; 2 symbols: p < 0.01; 3 symbols: p < 0.001. Dotted line, mean value of Control; GS, Gold Standard; VE, Vein; VE-cEV, Vein-cryoconserved extracellular vesicles; VE-fEV, Vein-freshly purified extracellular vesicles