Skip to main content
. Author manuscript; available in PMC: 2025 Nov 24.
Published in final edited form as: N Engl J Med. 2025 May 18;392(21):2100–2112. doi: 10.1056/NEJMoa2414059

Table 3.

Safety outcomes.

Bronchoscopy (n=121) Transthoracic Biopsy (n=113) Difference (95% CI) P value
Any complication 6 (5.0%) 33 (29.2%) 24.2% (15.0 to 35.6) <0.01
Pneumothorax 4 (3.3%) 32 (28.3%) 25.0% (15.3 to 34.8) <0.01
 Grade 1–2 (observation or aspiration) 3 (2.5%) 19 (16.8%) 14.3% (6.0 to 22.6) <0.01
 Grade 3–4 (admit +/− chest tube) 1 (0.8%) 13 (11.5%) 10.7% (3.7 to 17.6) <0.01
 Chest tube duration, d 1.0 (1.0 to 1.0) 1.0 (1.0 to 2.0) 0 0.65
Respiratory failure requiring admission 1 (0.8%) 1 (0.9%) 0.1% (−2.5 to 2.4) 0.96
Hemorrhage requiring intervention 0 0 0
Acute coronary syndrome 1 (0.8%) 0 0.8% (−1.6 to 3.3) 0.33