Table 2.

Log₂(FC) 99% CI and limma unadjusted p-values of genes and proteins that were differentially expressed or secreted (P<0.05, bold) in more than one of the transcriptomic, secretomic and proteomic analyses (Mrc2 E990G-het vs. WT).

	ACF transcriptome		ACF secretome		Atrial transcriptome		Atrial proteome
Gene/protein	Log2(FC) CI	p-value	Log2(FC) CI	p-value	Log2(FC) CI	p-value	Log2(FC) CI	p-value
Mmp12	(−1.09, −0.33)	0.002	(−2.00, 0.25)	0.031	(−1.80, 1.22)	0.626	Not detected
Cass4	(−3.45, 0.49)	0.040	Not detected		(−1.90, 0.14)	0.049	Not detected
Dpep2	(−1.43, −0.08)	0.019	Not detected		(0.05,1.86)	0.020	Not detected
Fgf10	(−3.02, −0.33)	0.004	Not detected		(0.07, 1.88)	0.019	Not detected
Gm28439	(−2.11, −0.02)	0.016	Not detected		(0.12, 2.97)	0.010	Not detected
Rpgrip1	(−0.19, 2.27)	0.033	Not detected		(0.08, 1.85)	0.018	Not detected
Tmod1	(−1.76, −0.25)	0.006	Not detected		(0.12, 1.19)	0.023	(−0.84, 0.38)	0.587
Fam174b	(−2.19, 0.18)	0.034	Not detected		(−0.45, 0.34)	0.945	(−7.08, −0.09)	0.009
Akap9	(−1.33, 0.61)	0.395	Not detected		(0.37, 1.55)	0.002	(1.26, 7.67)	0.002
Pdap1	(−0.38, 0.30)	0.984	Not detected		(0.03, 1.20)	0.049	(0.35, 2.67)	0.004
Prrc2c	(−0.21, 0.28)	0.995	Not detected		(0.15, 0.98)	0.025	(−0.46, 4.17)	0.031
Sds	(−0.76, 0.86)	0.913	Not detected		(−1.76, 0.03)	0.034	(−4.15, −0.39)	0.005
Tcof1	(−0.35, 0.27)	0.986	Not detected		(0.10, 1.17)	0.029	(0.21, 5.48)	0.008
Xirp2	Not detected		Not detected		(−0.05, 1.58)	0.046	(−0.30, 5.87)	0.018
Ylpm1	(−0.21, 0.38)	0.967	Not detected		(0.22 1.21)	0.009	(−0.06, 6.76)	0.012

Abbreviations: ACF – atrial cardiofibroblast, CI – confidence interval, FC – fold change, Het – heterozygous, limma – Linear Models for Microarray Data R package, WT – wild-type