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. 1965 Oct;97(1):139–147. doi: 10.1042/bj0970139

The effect of ultraviolet irradiation on soluble collagen

D R Cooper 1, R J Davidson 1
PMCID: PMC1264553  PMID: 16749094

Abstract

1. The effect of ultraviolet irradiation on acid-soluble and neutral-salt-soluble calf-skin collagen was studied by chromatography, gel filtration, amino acid analysis and sedimentation of the sub-units, and the reaction kinetics of degradation were obtained from viscosity and optical rotation measurements. 2. It was demonstrated that, whereas the structure of neutral-salt-soluble calf-skin collagen may be represented by the formula (α1)2α2, the acid-soluble extract has the formula α1.(α2)2. The acid-soluble collagen is also unusual in containing a large amount of a component that could be β22. 3. Ultraviolet irradiation causes the progressive degradation of the collagen molecule into smaller molecular fragments that subsequently lose their helical nature. The rate constants show that the denaturation of soluble collagens by ultraviolet irradiation is much slower, under the conditions used, than denaturation by heat or enzymes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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