Skip to main content
. 2025 Nov 11;12:1664674. doi: 10.3389/fnut.2025.1664674

Table 5.

Application of marine microalgal lipid as feed ingredient for livestock and poultry farming.

Microalgae Addition amount Aquatic animal Specific effects Reference
Schizochytrium limacinum 5 g/day Lamb (1) Compared with basal diet, microalgae contained much more PUFA a (62.5%), particularly DHA b (38.5%) and arachidonic acid (1.0%). (2) Feed efficiency and growth rate of lamb were improved by the supplementation of marine microalgae; (3) Blood cholesterol content tended to decrease (5.6%) in lambs fed marine microalgae; (4) Dietary supplement of microalgae improved total weight gain from 9.2 kg to 11.9 kg; (5) Dietary supplementation of marine microalgae did not change the concentrations of diamine oxidase, glutathione peroxidase, and free malondialdehyde. (119)
Nannochloropsis oceanica 123 g/kg of spray-dried biomass; 92 g/kg freeze-dried biomass; and 12 g/kg of microalgal oil Lamb (1) EPA contents in rumen, abomasum, and cecum of lamb fed freeze-dried marine microalgae were the highest; (2) PUFA contents in rumen and abomasum of lamb fed freeze-dried microalgae and microalgal oil were significantly higher than that of lamb fed spray-dried microalgae; (3) Freeze-dried marine microalgae is a natural rumen-protected source of EPA c to ruminants. (117)
Nannochloropsis oceanica 123 g/kg of spray-dried biomass; 92 g/kg freeze-dried biomass; and 12 g/kg of microalgal oil Lamb (1) Dietary supplementation of marine microalgae or microalgal oil improved daily fatty acid intake, particularly PUFA intake, of lamb; (2) In hippocampus and prefrontal cortex, brain fatty acid profile remained unchanged, with little alteration in docosapentaenoic acid enhancement; (3) Retinal tissues were particularly responsive to the dietary intervention, with a 4.5-fold enhancement of EPA in the lambs fed freeze-dried marine microalgae compared with the control lambs. (121)
Nannochloropsis oculata 750 g concentrate feed mixture with 10 g/kg microalgae per head each day Barki sheep (1) Dietary supplementation of Nannochloropsis oculata significantly up-regulated the expression pattern of immune and antioxidant markers in ewes post-lambing and their newly born lambs; (2) With the supplementation of microalgae, stillbirth of the newly born lambs was reduced from 30% to 10% and lamb birth weight was improved from 2.9 to 3.3 kg; (3) In ewes post-lambing, dietary intake of microalgae improved the contents of white blood cells and red blood cells and the activities of glutathione peroxidase and catalase, while reduced malondialdhyde content. (120)
Schizochytrium sp. 1%, 2%, and 3% Lamb (1) Inclusion of marine microalgae in diet reduced the ratios of n-6:n-3 in the fatty acid profiles of perirenal adipose tissue, skirt muscle, and subcutaneous adipose tissue of lambs; (2) Increase of marine microalgae supplementation in diet significantly improved the concentration of total PUFA in the subcutaneous adipose tissue of growing lambs; (3) Dietary intake of marine microalgae did not increase the concentration of PUFA in the skirt muscle of lambs; (4) Neither wool production nor quality was affected by dietary inclusion of marine microalgae in diet. (153)
NA a 8, 15, and 23 g/kg Dairy sheep (1) Supplementation of marine microalgae significantly improved PUFA content while reduced SFA d content in milk; (2) Addition of marine microalgae improved the concentrations of some bio-active components in milk. (127)
Schizochytrium sp. 100 and 200 g/bull/day Qaidamford cattle (1) Addition of microalgae in diet significantly increased the total antioxidant capacity in meat; (2) Microalgae supplementation increased the contents of PUFA, EPA, and DHA, while reduced the ratio of n-6/n-3 fatty acid; (3) Microalgae supplementation in diet did not have significant effects on the color parameters, such as lightness, redness, and yellowness, of physicochemical meat quality; (4) Sensory characteristics, including initial juiciness, sustained juiciness, flavor intensity, initial tenderness, sustained tenderness, of the beef from cattle fed microalgae-supplemented diet were improved. (125)
Schizochytrium limacinum 0.144 kg/cow/day Dairy cow (1) From Week 4 to Week 6, milk yield (35.4–38.5 kg/cow/day) of dairy cow fed marine microalgae was higher than that of cow in control group; (2) Dietary supplementation of marine microalgae improved the concentrations of PUFA and MUFA e in cow milk to 6.1 and 36.4 g/100 g FA f, respectively; (3) Cheese made with the milk from cow fed microalgae-supplemented diet had higher concentrations of PUFA (5.5 g/100 g FA) and MUFA (35.3 g/100 g FA); (4) Dietary intake of marine microalgae reduced the ratio of n-6:n-3 in the fatty acid profile of milk and cheese. (128)
NA 200 g/day (24% DHA of total FA) Dairy cow (1) Cow fed diet with DHA-rich microalgae had higher body weight in the experimental period; (2) Mammary gene expression was regulated by the dietary intake of marine microalgae. (1)
Schizochytrium sp. 170 and 255 g/day Dairy cow (1) Dietary intake of marine microalgae resulted in lower concentrations of total PUFA, but increased DHA concentration in milk; (2) With the increase of addition amount of marine microalgae, the ratio of n-3:n-6 in the fatty acid profile of milk; (3) DHA transfer efficiency from feeding microalgae to milk fell in a range of 10.1%−11.3%; (4) Dietary supplementation of marine microalgae did not have significant treatment effect on most of the blood hematological and biochemical parameters, except for platelets and thrombocytosis. (123)
NA 50, 100, and 150 g/day Dairy cow (1) Milk yield was improved from 18.0 to 19.3 kg/day with the increase of daily supplementation of algae; (2) Substitution of fish oil with algae had no effect on milk FA composition. (5)
Schizochytrium sp. 1.8 kg/day microalgae concentration (corresponding to 40 g DHA/day) Dairy cow (1) Dietary supplementation of marine microalgae created a milk fat depression but could not improve the energy balance.; (2) As measured by thiobarbituric acid reactive substances, feeding of DHA-rich microalgae significantly increased lipid peroxidation. (124)
Dunaliella salina 0.25, 0.50, and 1.00 g/kg Japanese quail (1) Compared with the control diet, diet with 0.5 and 1.0 g/kg microalgae significantly improved live body weight and body weight gain; (2) FCR was significantly reduced by the dietary supplementation of 0.5 and 1.0 g/kg microalgae; (3) Dietary supplementation of microalgae reduced the contents of total cholesterol and triglycerides; (4) With the addition of microalgae in diet, high density lipoprotein content increased while low density lipoprotein decreased. (113)
Schizochytrium sp. 20 g/kg Broiler (1) Broiler fed diet with marine microalgae had the highest body weight and feed intake values; (2) Dietary supplementation of marine microalgae had no effect on FCR g; (3) Meat of broiler fed diet with marine microalgae had the highest content of DHA; (4) Compared with salmon oil and flaxseed oil, marine microalgae resulted in a lower content of thiobarbituric acid reactive substances in the thigh meat in broiler chicken. (112)
Dunaliella salina and Spirulina sp. 0.5, 1.0, 1.5, and 2.0 g/kg (1 Dunaliella salina:1 Spirulina) Broiler (1) The lipid profile of broiler was improved through a reduction of total cholesterol and low-density lipoprotein contents; (2) Malondialdehyde contents in the blood samples of broilers fed 0.5, 1.0, and 1.5 g/kg microalgae were lower than that in control group; (3) Dietary supplementation of microalgae reduced the contents of Escherichia coli and Salmonella, but increase the content of lactic acid bacteria in the cecal fresh content of broiler; (4) Activities of digestive enzymes, including amylase, lipase, and protease, in broilers fed 1.0 g/kg microalgae were significantly higher than the activities of digestive enzymes of broilers in the control group. (2)
Schizochytrium limacinum 0.25, 0.50, 0.75, and 1.00% Laying hen (1) Microalgae supplementation in diet significantly improved the content of PUFA in eggs and reduced the ratio of n-6/n-3; (2) Microalgae did not have significant effects on average daily feed intake, FCR, egg weight, and shell thickness. (122)
Schizochytrium sp. 1.6% and 3.2% microalgae powder; 0.8% microalgae power plus 0.3% microalgae oil Laying quail (1) The 0.8% microalgae powder plus 0.3% microalgae oil group exhibited a reduction in daily egg-laying rate and egg mass, alongside an increased FCR; (2) Compared with the control group, supplementation of 3.2% microalgae powder significantly decreased the contents of total cholesterol and triacylglycerol in serum lipids of quails; (3) Dietary intake of microalgae powder and microalgae oil significantly improved the contents of PUFA, DHA, and n-3 PUFA in quail egg yolks. (130)
Dunaliella salina and Spirulina platensis 0.5, 1.0, 1.5, and 2.0 g/kg Laying Japanese quail (1) Addition of microalgae had no significant effect on egg production, egg weight, and egg mass; (2) Microalgae supplementation in diet significantly improved body weight and feed intake of laying quails but had no significant effect on FCR; (3) In terms of fertility and hatchability, 1.0 g/kg is the optimal addition amount of microalgae in quail diet; (4) Dietary intake of microalgae reduced the contents of total cholesterol and triglycerides while did not affect IgG and IgM levels in laying quails. (129)
Dunaliella salina 0.50, 1.00, and 1.50 g/kg Laying hen (1) Dietary intake of microalgae (15 days) reduced FCR to 2.04-2.27 and improved egg production to 77.9-88.6%; (2) The contents of albumin and globulin in eggs were improved by microalgae-supplemented diet; (3) Microalgae supplementation in diet improved carotenoid content in egg yolk and increased DHA content in egg. (116)
Dunaliella salina 0.25, 0.50, 0.75, and 1.00% Laying hen (1) In three experimental periods (Week 40–44, Week 44–48, and Week 48–52), egg weight was improved with the increase of microalgae supplementation while FCR was reduced; (2) Dietary intake of marine microalgae improved albumen weight, yolk weight, and yolk index of chicken eggs; (3) Supplementation of marine microalgae in chicken diet significantly increased total carotenoids content and intensity of red of egg yolk while slightly reduced luminosity of yolk; (4) Inclusion of marine microalgae in chicken diet provided a linear increase in intestinal villus height and ratio of crypt depth/villus height in the duodenum segments and ileum. (115)

a PUFA, Polyunsaturated fatty acid; b DHA, Docosahexaenoic acid; c EPA, Eicosapentaenoic acid; d SFA, Saturated fatty acid; e MUFA, Monounsaturated fatty acid; f FA, Fatty acid; g FCR, Feed conversion ratio.