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. 2025 Nov 17;18(11):1745. doi: 10.3390/ph18111745
FGFR Fibroblast growth factor receptor
FGF Fibroblast Growth Factor
TKI Tyrosine Kinase Inhibitor
SAR Structure–Activity Relationship
IC50 Half maximal inhibitory concentration
Kd Dissociation constant
MD Molecular Dynamics
ERK Extracellular Signal-Regulated Kinase
MEK Mitogen-Activated Protein Kinase Kinase
MAPK Mitogen-Activated Protein Kinase
PI3K Phosphoinositide 3-kinase
AKT Protein Kinase B
TACC3 Transforming Acidic Coiled-Coil containing protein 3
TNBC Triple-Negative Breast Cancer
NSCLC Non-Small Cell Lung Cancer
HCT116 Human colorectal carcinoma cell line
RT4 Human bladder cancer cell line
SRB Sulforhodamine B
ADME Absorption, Distribution, Metabolism, and Excretion
CYP Cytochrome P450
hERG Human Ether-à-go-go-Related Gene (potassium channel)
MS Mass Spectrometry
HRMS High-Performance Liquid Chromatography
UV Ultraviolet
ESI Electrospray Ionization
FAB Fast Atom Bombardment
CLint Intrinsic Clearance
SEM Standard Error of the Mean
SD Standard Deviation
EDC 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimmide
DMAP 4-Dimethylaminopyridine
DIAD Diisopropyl azodicarboxylate
DBU 1,8-Diazabicyclo[5.4.0]undec-7-ene
PEt3 Triethylphosphine
TBSCl tert-Butyldimethylsilyl chloride
TBAF Tetra-n-butylammonium fluoride
TBDPS tert-Butyldiphenylsilyl
DPPA Diphenylphosphoryl azide
TCDI 1,1′-Thiocarbonyldiimidazole
DMSO Dimethyl sulfoxide
ACN Acetonitrile
EtOAc Ethyl acetate
THF Tetrahydrofuran
DMF Dimethylformamide
MeOH Methanol