PBPK	Physiologically based pharmacokinetic
PK	pharmacokinetics
PD	pharmacodynamic
FDA	the U.S. Food and Drug Administration
DDI	drug–drug interaction
EMA	European Medicines Agency
NMEs	New Molecular Entities
NDA	New Drug Application
BLA	Biologics License Application
DGI	drug–gene interaction
OI	organ impairment
P-gp	P-glycoprotein
IVIVE	in vitro-in vivo extrapolation
AUCinf	area under the plasma concentration-time curve extrapolated to infinity
AUC	area under the curve
fm	fraction metabolized
UGT	UDP-glucuronosyltransferases
AI	artificial intelligence
ML	machine learning
RL	Reinforcement Learning
GANs	Generative adversarial networks