TABLE 2.

Processivity values of est2^LT alleles

Strain	Processivity(+3)a (n)	% Changeb	Significancec
EST2	0.228 ± 0.009 (6)
est2FCA720WCG	0.298 ± 0.007 (4)	+31	P ≤ 0.002
est2N95A	0.229 ± 0.005 (4)	+0.4	P ≤ 0.91
est2E76K	0.216 ± 0.030 (4)	−5.0	P ≤ 0.38

^aProcessivity⁽⁺³⁾ refers to the frequency with which telomerase synthesizes past the third position. See Materials and Methods for details of calculation. Standard deviation (±) is indicated as well as the number of independent samples (in parentheses).

^bPercent change of processivity⁽⁺³⁾ from wild type is calculated using the average values shown in the second column.

^cSignificance values were determined relative to wild type using a Student t test.