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Proposed model for the general molecular mechanism of USF2 transcriptional activity by LysRS and Ap4A. Following a specific stimulus, LysRS produces Ap4A in close proximity to the multiprotein complex LysRS/USF2/Hint. Ap4A then binds to Hint and liberates USF2, thus allowing USF2 to transactivate its target genes that are involved in physiological processes such as carcinogenesis and diabetes.
