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. 2025 Nov 26;16:2173. doi: 10.1007/s12672-025-03989-9

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Expression of FSTL1 in colon cancer and its clinical significance. ABoxplot illustrating the expression differences ofFSTL1 in normal and colon cancer tissues using data from the GEO database (GSE39582). B, CSurvival differences associated with different expression levels of FSTL1 in two GEO datasets (GSE16125 and GSE29621). DKRAS mutation differences at different expression levels ofFSTL1. EClinical stage differences at different expression levels ofFSTL1. F AJCC stage differences at different expression levels of FSTL1. GT stage differences at different expression levels ofFSTL1. (H) N stage differences at different expression levels of FSTL1. I M stage differences at different expression levels ofFSTL1.* p<0.05; ** p<0.01; *** p<0.001.;NS: not statistically significant.