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. 2025 Nov 26;16:2173. doi: 10.1007/s12672-025-03989-9

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — Single-cell sequencing analysis and cell communication analysis of FSTL1 in colon cancer. A Annotate the colon cancer single-cell dataset GEO (GSE178341) as seven types of UMAP plots. B Display a bubble plot of marker genes corresponding to different cell types. C, D Density plots and feature plots respectively show the expression levels ofFSTL1 in different cell types. E Display the cell communication intensity of FSTL1 in different cells. F A bubble plot shows the regulation of receptors and ligands between different cells by FSTL1.