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Differences in the activation of the S6K1 arm of the mTOR signaling pathway in TRAIL-sensitive versus TRAIL-resistant GBM cells. TRAIL-sensitive (U87 and U251) or TRAIL-resistant (U373 and A172) cells were analyzed for expression of phosphorylated (activated) Akt, phospho-S6K1, phospho-S6, 4E-BP1, eIF4E, and FLIPS by Western blotting. Values listed are the means derived from three independent experiments. *, P < 0.05.
