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TNF-α production by macrophages and lymphocytesa
| Macrophage or lymphocyte | Control (pg/ml) | LPS (pg/ml) | PHA and PMA (pg/ml) | GM-CSF (pg/ml) |
|---|---|---|---|---|
| Macrophages | ||||
| −308GG | 5.0 (2.2) | 629 (254) | 7.2 (2.8) | |
| −308GA | 6.1 (3.2) | 1,106 (363) | 10.2 (4.9) | |
| (P = 0.10) | (P < 0.0001) | (P = 0.001) | ||
| Lymphocytes | ||||
| −308GG | 7.4 (6.1) | 583 (334) | ||
| −308GA | 9.6 (7.8) | 958 (481) | ||
| (P = 0.15) | (P = 0.001) |
Values in parentheses are standard deviations.
