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. 2005 Oct;25(20):8864–8873. doi: 10.1128/MCB.25.20.8864-8873.2005

FIG. 9.

FIG. 9.

DNA binding inhibition by LMCD1/dyxin defines a new mechanism to restrict GATA factor function. (A) LMCD1/dyxin represses GATA6 function through inhibition of DNA binding. Strict control over cellular localization of LMCD1/dyxin may define its regulatory function. (B) GATA factors also interact with a variety of corepressors, such as FOG-1/2. These interactions repress GATA function by recruiting repression function in trans, sometimes through interaction with additional corepressor proteins such as CtBP-1 (8, 15, 34). Both models effectively restrict GATA factor activity.