TABLE 3.
Mutation rates at CAN1, his1-7, hom3-10 and his7-2
| Strain |
CAN1
|
his1-7
|
hom3-10
|
his7-2
|
||||
|---|---|---|---|---|---|---|---|---|
| Mutation rate (10−7)a | Increase (fold)b | Mutation rate (10−7)a | Increase (fold)b | Mutation rate (10−8)a | Increase (fold)b | Mutation rate (10−9)a | Increase (fold)b | |
| PMS1 | 4.3 (3.4-5.2) | 1 | 2.6 (1.1-4) | 1 | 1.01 (0.13-2) | 1 | 5.9 (3.8-8) | 1 |
| pms1Δ | 71 (50-92) | 17 | 23 (14-32) | 9 | 1,170 (400-1947) | 1,100 | 1020 (990-1,050) | 172 |
| pms1-G882E | 13 (8.4-17) | 3 | 4.4 (3.2-5.5) | 1.7 | 4 (3.1-4.9) | 3.7 | 329 (277-381) | 56 |
| pms1-H888R | 20 (17-23) | 4.7 | 8 (4.2-11.7) | 3.1 | 3.6 (2.7-4.5) | 3.4 | 903 (821-984) | 153 |
a
Values in parentheses are 95% confidence intervals.
b
Increases are calculated relative to PMS1.