TABLE 6.
Genetic interactions between pms1 alleles and msh2Δ, pol2-C1089Y
| Strain |
CAN1
|
his7-2
|
||
|---|---|---|---|---|
| Mutation rate (10−7)a | Increase (fold)b | Reversion rate (10−9)a | Increase (fold)b | |
| PMS1 MSH2 POL2 | 4.3 (3.4-5.2) | 1 | 5.9 (3.8-8) | 1 |
| pms1Δ | 71 (50-92) | 17 | 1,020 (990-1,050) | 172 |
| pms1-G882E | 13 (8.4-17) | 3 | 329 (277-381) | 56 |
| pms1-H888R | 21 (17-24) | 4.7 | 903 (821-984) | 153 |
| msh2Δ | 66.1 (49-83) | 15 | 1,450 (1,160-1,740) | 246 |
| msh2Δ pms1Δ | 51 (33-69) | 11.8 | 1,260 (910-1,600) | 214 |
| msh2Δ pms1-G882E | 54 (32-75) | 12.6 | 1,330 (520-2,130) | 225 |
| msh2Δ pms1-H888R | 61.7 (26-98) | 14.3 | 1,350 (1,200-1,490) | 229 |
| pol2-C1089Y | 16 (11-21) | 3.7 | 290 (30-551) | 49 |
| pms1Δ pol2-C1089Y | 890 (454-1,300) | 206 | 32,260 (7,000-57,530) | 5,468 |
| pms1-G882E pol2-C1089Y | 372 (248-495) | 86 | 26,000 (8,800-43,200) | 4,406 |
| pms1-H888R pol2-C1089Y | 356 (272-440) | 83 | 38,200 (3,160-73,240) | 6,475 |
a
Values in parentheses are 95% confidence intervals.
b
Increases are calculated relative to PMS1.