FIG. 2.

Macroscopic observation of Line 239 mice. (A) Twelfth day after birth. Note that skin lesions are not apparent. (B) Fifth week. An eczematous change emerges on the back skin. (C) Tenth week. Erosive dermatitis with crusts is observed. (D) Twentieth week. Note that re-epithelialization follows, and the fur coat is completely lost. (E and F) Observation of behaviors related to skin itching. The total duration of grooming behavior within 10 min was measured for three independent mice, and the averages and standard deviations are shown in panel E. The frequency of scratching episodes within 10 min was counted for three independent mice, and the averages and standard deviations are shown in panel F. The differences between the AhR-CA mice (TG) and the wild-type control mice (WT) are statistically significant (P < 0.05).