FIG. 4.

Altered gene expression profiles in the skin of AhR-CA mice. (A) A total of 309 genes increased by >4-fold are categorized into nine groups. The percentage of each category is shown. (B) The ratios of the genes increased (black areas) or deceased (gray areas) by >2-fold are shown within each gene subcategory. The number written in the center of each circle graph indicates the number of genes included in that subcategory. (C) The expression levels of representative genes were examined by semiquantitative RT-PCR. cDNAs were synthesized from the skin RNAs of 10-day-old AhR-CA and wild-type mice. The corresponding line numbers are shown at the top. M, male; F, female; WT, wild type.