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. 2005 Nov;25(21):9360–9368. doi: 10.1128/MCB.25.21.9360-9368.2005

FIG. 5.

FIG. 5.

Spontaneous deviation of splenic lymphocytes into Th2 cells. (A) High serum levels of IgE and IgG1 in AhR-CA mice. Sera from the AhR-CA mice (n = 13) and their wild-type littermates (n = 12) aged from 7 to 14 weeks were sampled. The serum levels of various types of immunoglobulins (IgG2a, IgG3, IgM, IgE, and IgG1) were measured by ELISA. Differences in the levels of IgE and IgG1 are statistically significant between the transgenic mice and controls (P < 0.05). (B) Increased production of IL-4 and IL-5 from the anti-CD3 stimulated splenic lymphocytes. Splenic lymphocytes were prepared from the AhR-CA mice (n = 7) and their wild-type littermates (n = 8) aged from 7 to 14 weeks and then stimulated with anti-CD3 antibody. The cytokine concentrations (IL-4, IL-5, IFN-γ, and IL-2) in each supernatant were determined by ELISA. Differences in the levels of IL-4 and IL-5 are statistically significant between the transgenic mice and their controls (P < 0.05).