TABLE 1.
Genes increased in the skin of AhR-CA mice
| Gene category | Gene subcategory | Accession no. | Gene | Fold change |
|---|---|---|---|---|
| Detoxifying enzymes | Detoxifying enzymes and genes | NM009644 | Aryl-hydrocarbon receptor repressor | 16.6 |
| NM009992 | Cytochrome P450, 1a1 | 44.2 | ||
| NM009994 | Cytochrome P450, 1b1 | 4.0 | ||
| NM007825 | Cytochrome P450, 7b1 | 3.7 | ||
| AV158882 | NAD(P)H dehydrogenase, quinone 1 | 3.8 | ||
| NM010357 | Glutathione S-transferase, alpha 4 | 8.2 | ||
| NM008184 | Glutathione S-transferase, mu 6 | 2.0 | ||
| NM008161 | Glutathione peroxidase 3 | 2.7 | ||
| Interleukins, chemokines, and receptors | Interleukins and their receptors | AF000304 | IL-4 receptor, alpha | 15.1 |
| L20048 | IL-2 receptor, gamma chain | 8.0 | ||
| D13695 | IL-1 beta | 6.0 | ||
| NM008360 | IL-18 | 2.2 | ||
| Chemokines | BC002073 | Chemokine (C-C motif) ligand 6 | 18.5 | |
| NM009141 | Chemokine (C-X-C motif) ligand 5 | 22.2 | ||
| AF099052 | Chemokine (C-C motif) ligand 20 | 14.9 | ||
| NM008176 | Chemokine (C-X-C motif) ligand 1 | 8.9 | ||
| NM011888 | Chemokine (C-C motif) ligand 19 | 8.4 | ||
| NM021443 | Chemokine (C-C motif) ligand 8 | 6.3 | ||
| Immunological proteins | Fc receptors | NM010185 | Fc receptor, IgE, high-affinity I, Gamma polypeptide | 23.9 |
| BM224327 | Fc receptor, IgG, low-affinity IIb | 6.8 | ||
| Antimicrobial peptide | NM019728 | Defensin beta 4 | 38.3 | |
| NM013756 | Defensin beta 3 | 11.0 | ||
| Structure proteins | Keratins | NM010669 | Keratin 6b | 35.1 |
| NM008470 | Keratin 16 | 7.8 | ||
| NM008473 | Keratin 1 | 6.1 | ||
| Proteases and inhibitors | Proteases | NM008572 | Mast cell protease 8 | 11.1 |
| NM008571 | Mast cell protease 2 | 2.8 | ||
| NM008607 | Matrix metalloproteinase 13 | 34.8 | ||
| AV375008 | Matrix metalloproteinase 19 | 9.1 | ||
| NM013599 | Matrix metalloproteinase 9 | 3.3 |