TABLE 2.
Echocardiography of p85α mKO 85β−/− mice reveals normal cardiac functiona
| Genotype | LVPW (mm) | IVS (mm) | EDD (mm) | ESD (mm) | FS (%) | HR (beats/min) |
|---|---|---|---|---|---|---|
| WT | 0.68 ± 0.05 | 0.82 ± 0.03 | 3.57 ± 0.11 | 2.20 ± 0.05 | 38 ± 1 | 453 ± 20 |
| p85α loxP/loxP p85β−/− | 0.64 ± 0.03 | 0.78 ± 0.04 | 3.26 ± 0.20 | 2.02 ± 0.27 | 39 ± 4 | 446 ± 18 |
| p85α mKO p85β−/− | 0.65 ± 0.06 | 0.77 ± 0.04 | 3.13 ± 0.10 | 2.00 ± 0.10 | 36 ± 2 | 478 ± 6 |
a
Female mice at the age of 18 to 20 weeks were analyzed (n = 5 to 6 per genotype). Results shown are means±standard errors of the means. LVPW, left ventricular diastolic posterior wall thickness; IVS, interventricular septum thickness; EDD, left ventricular end diastolic dimension; ESD, left ventricular end systolic dimension; FS, fractional shortening; HR, heart rate.