TABLE 3.
Swim training of p85α mKO 85β−/− mice reveals attenuated cardiac hypertrophya
| Genotype | Training | BW (g) | TL (mm) | HW (mg) | LW (mg) | HW/BW | HW/TL |
|---|---|---|---|---|---|---|---|
| WT | Ctrl | 21.8 ± 0.4 | 16.2 ± 0.1 | 91.6 ± 2.2 | 123.9 ± 3.1 | 4.2 ± 0.1 | 5.6 ± 0.1 |
| Swim | 22.3 ± 0.5 | 16.4 ± 0.1 | 114.9 ± 2.9d | 136.5 ± 2.7 | 5.1 ± 0.1d | 7.0 ± 0.1d | |
| p85α loxP/loxP p85β−/− | Ctrl | 22.8 ± 0.8 | 16.5 ± 0.1 | 96.3 ± 2.7 | 126.7 ± 4.2 | 4.2 ± 0.1 | 5.8 ± 0.2 |
| Swim | 21.0 ± 0.7 | 16.2 ± 0.2 | 110.8 ± 4.2d | 122.3 ± 5.6 | 5.3 ± 0.1d | 6.8 ± 0.2d | |
| p85α mKO p85β−/− | Ctrl | 20.9 ± 1.4 | 16.0 ± 0.2 | 74.2 ± 4.4b | 115.6 ± 8.4 | 3.6 ± 0.1c | 4.6 ± 0.2c |
| Swim | 19.8 ± 0.6 | 16.0 ± 0.2 | 81.8 ± 2.3b,d | 116.5 ± 4.6 | 4.1 ± 0.1c,d | 5.1 ± 0.1c |
a
Mice at the age of 5 months with or without 4 weeks of swim training were analyzed (n = 5 to 9 per genotype). Results shown are means ± standard errors of the means. BW, body weight; TL, tibia length; HW, heart weight; LW, lung weight; Ctrl, control. Last two columns represent HW-to-BW and HW-to-TL ratios, respectively. Statistical analyses were determined by two-way ANOVA.
b
P of <0.01 compared to the same training group of the other two genotypes.
c
P of <0.001 compared to the same training group of the other two genotypes.
d
P of <0.001 compared to the nonswim control group of the same genotype.