TABLE 1.

T- and B-cell development in Sly1^d/d mutant mice^a

Organ	Subset	Mean % positive cells ± SD			Mean no. of cells/organ (106) ± SD
		Wild type	Sly1d/d	P	Wild type	Sly1d/d	P
Thymus	CD4− CD8−	3.6 ± 1.4	6.2 ± 1.2	<0.001	5.1 ± 1.8	5.7 ± 1.8	0.46
	CD4+ CD8+	81.6 ± 2.8	79.1 ± 2.7	<0.05	110.5 ± 25.9	59.9 ± 14.5	<0.001
	CD4+ CD8−	10.8 ± 1.4	9.0 ± 1.8	<0.01	18.7 ± 5.2	8.7 ± 3.9	<0.001
	CD8+ CD4−	3.5 ± 0.9	4.0 ± 1.1	0.21	5.4 ± 1.8	3.9 ± 1.2	0.10
Spleenb	CD4+	61.0 ± 1.8	49.2 ± 3.0	<0.001	14.2 ± 4.4	7.1 ± 1.5	<0.01
	CD8+	32.9 ± 1.5	39.7 ± 2.4	<0.001	6.9 ± 1.2	5.7 ± 1.1	0.11
	CD25+	2.0 ± 0.2	2.0 ± 0.1	0.86	1.2 ± 0.6	0.7 ± 0.2	0.20
	IgMhi IgDlo	6.2 ± 2.1	2.7 ± 1.0	<0.01	3.5 ± 0.9	1.3 ± 0.4	<0.01
	IgMlo IgDhi	32.3 ± 8.6	29.1 ± 11.8	0.62	23.9 ± 4.1	15.2 ± 9.8	0.15
Bone marrow	B220lo IgM−	29.9 ± 6.0	25.0 ± 6.4	0.29	9.4 ± 1.4	10.0 ± 2.2	0.69
	B220lo IgMlo	11.3 ± 6.0	13.8 ± 7.3	0.61	3.7 ± 1.7	6.2 ± 2.8	0.32
	B220hi IgMhi	7.0 ± 2.5	4.9 ± 2.5	0.26	2.0 ± 0.7	1.9 ± 1.0	0.16
Peritoneal cavity	IgMhi IgDlo	16.0 ± 2.3	17.2 ± 5.0	0.79	n.d.	n.d.	n.d.

^aData are means and are derived from 6 to 12 independent mice per group.

^bPercentages of CD4⁺ and CD8⁺ cells are relative to CD3⁺ cells, whereas percentages of CD25⁺ cells are relative to CD4 T cells.