Figure 5.

RAG^–/– mice show reduction in fibrosis development. RAG^–/– or WT BALB/c mice were gavaged with 1.75 ml/kg of CCl₄ or with mineral oil. One week following the sixth weekly treatment, mice were sacrificed; collagen-specific Sirius red staining of liver sections was performed (A), and interstial collagen deposition was quantified (B). A column of dots represents a series of sections from 1 animal; mean values are shown in red bars. Magnification for Sirius red staining, ×50.