6. DoE Experimental Results.
| Factor 1 |
Factor 2 |
Factor 3 |
Response 1 |
Response 2 |
Response 3 |
Response 4 |
|
|---|---|---|---|---|---|---|---|
| Std | A: n-Butyllithium Lithium (equiv) | B: Reaction Temp (°C) | C: Res. Time (s) | 15 (%) | 13 (%) | 14 (%) | 10 (%) |
| 1 | 1.8 | –60 | 0.50 | 1.68 | 3.76 | 10.81 | 0.70 |
| 2 | 3.0 | –60 | 0.50 | 7.97 | 3.58 | 0.01 | 0.10 |
| 3 | 1.8 | –40 | 0.50 | 2.43 | 3.26 | 9.33 | 0.47 |
| 4 | 3.0 | –40 | 0.50 | 11.30 | 2.15 | 0.01 | 0.10 |
| 5 | 1.8 | –60 | 2.00 | 2.79 | 6.20 | 0.03 | 0.10 |
| 6 | 3.0 | –60 | 2.00 | 14.43 | 4.76 | 0.01 | 0.10 |
| 7 | 1.8 | –40 | 2.00 | 5.00 | 11.55 | 17.5 | 0.86 |
| 8 | 3.0 | –40 | 2.00 | 22.87 | 5.20 | 0.03 | 0.10 |
| 9 | 2.4 | –50 | 1.25 | 5.97 | 4.38 | 0.02 | 0.10 |
| 10 | 2.4 | –50 | 1.25 | 7.99 | 4.54 | 0.03 | 0.10 |
| 11 | 2.4 | –50 | 1.25 | 7.61 | 3.70 | 0.02 | 0.10 |