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. 2025 Nov 10;10(46):55920–55931. doi: 10.1021/acsomega.5c07458

7. Point Prediction Based on DoE Study.

Factor Name Level Low Level High Level Std. Dev.
A n-Butyllithium 2.0 1.8 3 0
B Reaction temperature –50 –60 –40 0
C Residence time 1.5 0.5 2 0
Response Prediction SE Mean 95% CI Low 95% CI High SE Pred 95% PI Low 95% PI High
15 8.55875 0.588801 7.04519 10.07231 2.039665 3.315624 13.8018757
13 5.0575 0.13448 4.47888 5.63612 0.465852 3.0531 7.061899822
14 4.71625 0.001741 4.70876 4.72374 0.00603 4.690304 4.742195972
10 0.31625 0 0.31625 0.31625 0 0.31625 0.31625