Figure 7.

Impact of CD36 gene invalidation on the changes in pancreato-biliary flux (A) and protein levels (A) triggered by a lingual linoleic acid deposition. Anesthetized wild-type and CD36-null mice with pancreato-biliary diversion and esophageal ligation to prevent any lipid ingestion were subjected to an oral load with linoleic acid (0.2 ml). Controls received 0.2 ml water by the same route. Black and white bars correspond to pancreato-biliary flux before and after lingual linoleic acid deposition, respectively. The functional validity of preparations was assessed by a duodenal HCl infusion (gray bars). Data represent mean ± SEM; n = 9. *P < 0.05; **P < 0.01; ^#P < 0.001.